Clinicopathologic and genetic characteristics of gastric cancer in young male and female patients.
نویسندگان
چکیده
The pathways of gastric cancer in young patients (40 years of age or younger) have not yet been determined. We therefore examined clinicopathologically and genetically 68 gastric cancers in young patients and 66 tumors in older patients (41 years of age or older). Mutations in B-raf and K-ras were identified by PCR-SSCP following sequencing. Microsatellite instability (MSI) and hMLH3 mutations were also examined. Histopathologically, diffuse-type gastric cancer and cancer in the whole of the stomach were found significantly more often in young patients than in older patients (21% vs. 2%, P = 0.0006, and 77% vs. 32%, P < 0.0001, respectively). Genetically, MSI and hMLH3 mutations were found significantly more often in tumors in young patients than in tumors in older patients (15% vs. 4%, P = 0.040, and 9% vs. 0%, P = 0.036, respectively). Tumors in young female patients were found significantly less often in the lower-third of the stomach and showed a significantly greater frequency of MSI, compared to tumors in young male patients (33% vs. 9%, P = 0.046, 5% vs. 30%, P = 0.010, respectively). These results suggest that the pathways of gastric carcinogenesis differ between young patients and older patients, and that the pathways differ between the sexes in young patients.
منابع مشابه
Clinicopathologic Characteristics and Prognosis of Gastric Cancer in Young Patients
To determine the clinicopathologic characteristics and prognosis of gastric cancer in young patients, a total of 1985 gastric cancer patients who had undergone gastrectomy at our hospital were reviewed. The male-to-female ratio was significantly lower in the young patients than in either the middle-aged (P < 0.0001) or elderly patients (P < 0.0001). Undifferentiated carcinoma was observed more ...
متن کاملGastric Cancer in people below and above 40 is it different?
Abstract Background: Gastric cancer is the second most common cancer and also the second cancer related death all over the world. In recent years recorded data for tumor has shown a rise in the incidence of gastric cancer in young individuals. The present study was designed to compare some of the epidemiologic characteristics of individuals suffering from gastric cancer aged below a...
متن کاملAssociation between pre-chemotherapy serum levels of vitamin D and clinicopathologic findings in gastric cancer
Background: To examine serum levels of vitamin D in newly diagnosed gastric cancer (GC) patients compared with normal subjects and any possible association with prognostic variables. Methods: One-hundred subjects (50 GC and 50 controls) were enrolled and serum vitamin D levels were assessed using ELISA. Based on two definitions, vitamin D was classified as a sufficient level (≥30 ng/dL) and op...
متن کاملSurvival in Nonmetastatic Gastric Cancer Patients
Background & Aims: Gastric carcinoma is the second most frequent cancer worldwide. Adjuvant treatment of gastric cancer varies worldwide; many differences have been observed in their clinical and pathological features, and survival rate. The aim of this study was to determine clinical and pathological features, and survival rate in a group of patients in south-east of Iran. Methods: Patient rec...
متن کاملبرآورد بقا و تعیین عوامل مرتبط با بقای بیماران مبتلا به سرطان معده آدنوکارسینوم در بیمارستان شهید فیاضبخش تهران
Background : Adenocarcinoma is the most type of gastric cancer. Survival of patients in this type is shorter than other gastric cancers. In this study survival of adenocarcinoma gastric cancer analyzed. Methods : In this study, 99 Adenocarcinoma patients that referred to Fayazbakhsh hospital in 2007 and 2008 recruited. Effect of gender, age, Grade, site of tumor, type of treatment, size of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Oncology reports
دوره 16 1 شماره
صفحات -
تاریخ انتشار 2006